2019
Micellar and solubility properties of drug tetracaine-hydrochloride from thermal conductivity measurements
La revue : Journal of Molecular Liquids
Domaine :
Mots Clés :
Auteur : C Zelmat, T Fergoug, M Azayez, N Meddah, F Chater, H Boudjoras, Y Bouhadda
Issn : Eissn : vol : 293, Num : , pp : 111572
Résume :

Solubility and micelle formation of tetracaine-hydrochloride (TC,HCl) in aqueous solution has been studied by thermal conductivity. From thermal variations of the specific conductivity, parameters such as the critical micelle concentration, cmc, Krafft temperature, TK, and the variation of solubility with temperature were determined. The cmc's data analysis according to the mass action model has enabled to determine free energies of adsorption and of the micelles formation. A partial phase diagram of TC,HCl in water was also deduced and the micellization process discussed in light of enthalpy and entropy contributions.

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